Gender-responsive evaluation is a powerful tool for learning, decision-making and accountability that supports the achievement of gender equality and women’s empowerment. As such, it is a priority for the United Nations Entity for Gender Equality and the Empowerment of Women (UN Women). As part of efforts to professionalize the evaluation function of UN Women, the Independent Evaluation Office (IEO), Human Resources and the UN Women Training Centre are collaborating to develop a comprehensive, hands-on professionalization programme for UN Women staff. One aspect of this approach is the issuance of this Evaluation Handbook and a corresponding e-learning course (to be launched in 2015) on how to manage a gender-responsive evaluation at UN Women. We are confident that this initiative will complement other ongoing efforts to strengthen the quality of evaluations, ultimately leading to better use of evaluation for decision-making, accountability and learning on what works for gender equality and women’s empowerment.